TH-588 hydrochloride
CAS No. 1640282-30-9
TH-588 hydrochloride ( TH588 hydrochloride )
Catalog No. M12485 CAS No. 1640282-30-9
A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
|
50MG | 1782 | Get Quote |
|
100MG | 2250 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTH-588 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.
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DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 5 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
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SynonymsTH588 hydrochloride
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1640282-30-9
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Formula Weight331.63
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Molecular FormulaC13H13Cl3N4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CC1NC2=NC(=NC(=C2)C3=C(C(=CC=C3)Cl)Cl)N.Cl
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Chemical Name2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.
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